A drug that helps eliminate #Alcoholism. #Blocks the release of endorphins on opioid receptors, so drinkers fail to get that "feel good" feeling from drinking, retrainng the brain. Shouldn't there be a @NobelPrize for womever blocks all opioId receptors against endorphins from ALL manner of elicit opioids? And one for Tobacco, whichever receptors nicotine "hits"? Wouldn't this stop the #DrugTrade? The problem is one side effect is that you can't be on opioids. @DrEricDing@EricTopol@CDC@NIH@JohnsHopkins@RobertKennedyJr
The article refers to #naltrexone, a medication that blocks the brain's opioid receptors to blunt the "buzz" and rewarding effects of alcohol. First FDA-approved for alcohol dependence in 1994, it allows people with alcohol use disorder (AUD) or heavy drinking habits to successfully cut back on consumption without requiring strict, immediate abstinence. [1, 2, 3]
How Naltrexone Works
Blocks the Reward: When you drink, your brain releases endorphins (feel-good chemicals). Naltrexone blocks the receptors where these endorphins bind, effectively eliminating the euphoria or "tipsy" pleasure usually gained from alcohol. [1, 2, 3]
Provides a "Brake" Mechanism: Because the rewarding feeling is missing, the physical urge to have a second, third, or fourth drink is dramatically reduced. [1, 2]
Pharmacological Extinction: Over time, consistently blocking this reward train retrains the brain to stop associating alcohol with pleasure, causing cravings to fade. [1, 2]
The Two Main Approaches to Taking It
ApproachHow it WorksBest Used ForThe Sinclair Method (As-Needed)A 50mg pill is taken 1 to 2 hours before an anticipated drinking episode. You do not take it on days you do not drink.Individuals who want to reduce binge drinking or taper down their habits without giving up alcohol entirely.Daily Dosing / InjectionTaken as a daily oral tablet or given as a monthly extended-release injection (Vivitrol).Individuals aiming for total abstinence or those who need a constant safety net against cravings.
Why It's Barely Used
Despite being safe, highly effective, and incredibly inexpensive (generic versions can cost as little as $5 a month), less than 2% of the 29 million Americans with alcohol use disorder receive medication. [1]
The primary barriers include a historical "abstinence-only" dogma in addiction treatment, a general lack of training regarding addiction medications among primary care doctors, and rigid FDA criteria that traditionally evaluated alcohol clinical trials as "failures" if a patient didn't achieve 100% sobriety. [1, 2]
Important Safety Considerations
Not a Safety Shield: Naltrexone does not alter your blood alcohol concentration. You will still become physically impaired, uncoordinated, and legally drunk if you consume alcohol. [1]
Opioid Risk: Because it blocks opioid receptors, it cannot be taken by anyone currently using opioid pain medications or dealing with opioid withdrawal, as it will trigger immediate, severe withdrawal symptoms. [1, 2]
Side Effects: The most common side effects are temporary and include mild nausea, headaches, dizziness, and fatigue. [1, 2] @nationalGeographic
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